Dr. Andrew Mellor, Medical College of Georgia
Immunotherapy Center Director and Georgia Research Alliance Eminent Scholar in Immunogenetics
Immunotherapy Center - Vision and Mission The Immunotherapy Center is a new center of research excellence at the Medical College of Georgia. Many diseases develop because the immune system is over-active, as in autoimmune diseases (e.g. type I diabetes, rheumatoid arthritis, multiple sclerosis, lupus etc.), or under-active, as in cancer and chronic infectious diseases (e.g. HIV, Hepatitis, TB, Listeria, etc.). The primary role of the immune system is to eliminate microbial infections that cause pathogenic disease. To perform this key function immune cells must recognize and respond to 'foreign' molecules (antigens) expressed by invading pathogens leading to the destruction of pathogens and of cells they infect.
The
mission of the MCG Immunotherapy Center is to discover fundamental molecular mechanisms and cellular processes that control the immune system and to translate this new knowledge into innovative approaches to prevent and treat clinical disease. To achieve this goal, scientists using cell and animal model systems are working with clinical investigators and clinical faculty to increase understanding of immune system function and to apply this knowledge to treat disease in the clinic. In recognition of the critical role of the immune system in cancer etiology, the Immunotherapy Center will be relocated to the new Cancer Research Center in 2006, which is equipped with new research facilities to support basic and clinical research, including new facilities essential to promote studies on patient materials for pre-clinical research and experimental clinical trials.
Immunotherapy Center - Research Programs Research at the Immunotherapy Center is focused on fundamental mechanisms that regulate immune system activity, which help to prevent autoimmune diseases, but allow tumors and chronic infections to persist. Research goals are to discover how to manipulate these mechanisms to stimulate the immune system to attack tumors and infected cells, and to prevent the immune system destroying healthy cells and transplanted organs and tissues.
Immunotherapy Center - Leadership and Administration The MCG Immunotherapy Center is lead by Drs. Mellor and Munn who founded the Center in 2002.